Granulocyte function in myeloblastic leukaemia

Acute Myeloblastic Leukaemia

Myeloblastic leukaemia (A.M.L.) and its closely related cytological variants are less responsive to chemotherapy than acute lymphoblastic leukaemia (A.L.L.). A considerable problem still exists with remission induction; a high proportion of patients fail to achieve complete remission, especially among older adults with the disease. The contribution of maintenance chemotherapy after remission is...

Clonogenic cells in acute myeloblastic leukaemia.

N ORMAL granulocytes, monocytes, and erythrocytes are derived from small numbers of bone marrow progenitor cells that have extensive proliferative capacity. 3 In vitro cell culture techniques to identify progenitor cells have been available for 20 years and depend on the ability of these cells to form colonies of fully differentiated cells in semisolid medium in response to specific growth fact...

Association between acute myeloblastic leukaemia and sarcoidosis.

INTRODUCTION Sarcoidosis is a systemic granulomatous disorder thought to be an exaggerated immune response to unknown antigens. It often presents with bilateral mediastinal lymphadenopathy and/or pulmonary infiltrates (1). Sarcoidosis has been found in association with a variety of malignancies, including malignant myeloproliferative disorders (2). To date, only two cases of acute myeloblastic ...

Acute myeloblastic leukaemia presenting with erythema nodosum.

Aplastic anaemia, acute myeloblastic leukaemia, and oxymetholone.

Four patients developed acute myeloblastic leukaemia after treatment of aplastic anaemia with oxymetholone. Two had previously shown an excellent clinical response to the drug and a third some improvement. Though no definite causal relationship between therapy and the onset of leukaemia has been established, the number of cases is greater than might have been expected by chance. The association...